Antistaphylococcal Activity of Dx-619, Alone and in Combination with Vancomycin, Teicoplanin and Linezolid, by Time-kill Synergy Testing Kim Credito
نویسندگان
چکیده
Correspondence to: Dr. Peter C. Appelbaum Department of Pathology Hershey Medical Center P.0. Box 850 Hershey, PA 17033 Telephone no,: (717) 531-5113 Telefax no.: (717) 531-7953 E-mail: [email protected] AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01517-06 AAC Accepts, published online ahead of print on 29 January 2007
منابع مشابه
Antistaphylococcal activity of DX-619, a new des-F(6)-quinolone, compared to those of other agents.
The in vitro activity of DX-619, a new des-F(6)-quinolone, was tested against staphylococci and compared to those of other antimicrobials. DX-619 had the lowest MIC ranges/MIC(50)s/MIC(90)s (microg/ml) against 131 Staphylococcus aureus strains (</=0.002 to 2.0/0.06/0.5) and 128 coagulase-negative staphylococci (0.004 to 0.25/0.016/0.125). Among strains tested, 76 S. aureus strains and 51 coagul...
متن کاملIn vitro activity of linezolid alone and in combination with glycopeptides against methicillin-resistant Staphylococcus aureus
The emerging resistance to antibiotics and the poor pipeline of new antibacterials is creating a major health issue worldwide. Combinations of two antibiotics or antibiotics with adjuvant are emerging as a promising therapeutic approach. Staphylococcus aureus represents a major threat to a broad range of healthcare and community associated infections. It is imperative to develop novel antimicro...
متن کاملActivity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species.
Agar dilution MIC was used to compare activities of OPT-80, linezolid, vancomycin, teicoplanin, quinupristin/dalfopristin, amoxicillin/clavulanate, imipenem, clindamycin, and metronidazole against 350 gram-positive and -negative anaerobes. OPT-80 was active against gram-positive strains only, especially Clostridium spp. (85 strains tested, including 21 strains of C. difficile), with MICs rangin...
متن کاملAntistaphylococcal activity of dalbavancin, an experimental glycopeptide.
Dalbavancin, tested against 146 staphylococci, was more potent than other drugs tested, with an MIC at which 50% of staphylococci were inhibited of 0.03 microg/ml and an MIC at which 90% of staphylococci were inhibited of 0.06 microg/ml by microdilution. For all strains, MICs of vancomycin, linezolid, ranbezolid, oritavancin, daptomycin, and quinupristin-dalfopristin were </=4.0 microg/ml. Dalb...
متن کاملActivity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed by time-kill methodology.
The synergistic effects of daptomycin plus gentamicin or rifampin were tested against 50 Staphylococcus aureus strains, with daptomycin MICs ranging between 0.25 and 8 microg/ml. Daptomycin sub-MICs combined with gentamicin concentrations lower than the MIC yielded synergy in 34 (68%) of the 50 strains. Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus s...
متن کامل